What do we investigate?
Frontier exploration & disease scope governance
Topic Proposer
Scans active disease syntheses, entity registry, and knowledge boundary to propose high-yield next research frontier topics.
Review Committee Governance Panel
Audits proposed research sub-topics against the project's root disease objective to prevent semantic drift into generic biology or tangential pathways.
Aggregate prior knowledge
Exhaustive literature retrieval & verified extraction
Literature Discovery Worker
Searches 41M+ biomedical papers across PubMed, PMC, and bioRxiv via Firecrawl and INDRA causal graph.
Parallel Statement Extractor
Extracts atomic, directional biological claims with 100% verbatim quotes, protected by in-session verification regex hooks.
Statement QC Reviewer
Rigorous single-pass peer review validating evidence quote fidelity, signal-to-noise ratio, and causal directionality.
Make it reusable
Controlled ontology reconciliation & entity grounding
Global Vocabulary Harmonizer
Reconciles open relationship phrases into controlled integer predicate IDs and standardized context keys (Schema v4).
Entity Grounding & Conflict Worker
Reconciles biomedical mentions against HGNC, UniProt, ChEBI, and GO with Gilda and INDRA grounders.
Make it actionable
How does it work? What should we test?
Synthesizer
Authors disease syntheses attributed to statement IDs and formulates testable biological hypotheses with explicit falsification protocols.